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España – 22/Mar/2022
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Científicos del Centro de Regulación Genómica (CRG) de Barcelona han descubierto que fusionar células de la retina con células madre adultas despierta el potencial regenerativo de la retina humana, lo que abre la puerta a una futura estrategia terapéutica para tratar el daño retiniano y la discapacidad visual.
La investigación, que publica la revista eBioMedicine, ha comprobado que las células híbridas favorecen la capacidad regenerativa del tejido de la retina humana, un rasgo que se creía exclusivo de los vertebrados de sangre fría.
Los investigadores, liderados por Pia Cosma, estudiaron la posibilidad de que los eventos de fusión celular resultaran en células que se diferencian y se convierten en neuronas, lo que mostraría su potencial para regenerar tejidos..
Los autores del estudio creen que la retina puede tener un mecanismo que regula la segregación cromosómica similar al hígado, que contiene células tetraploides que actúan como reservorio genético, experimentando mitosis en respuesta al estrés y las lesiones.
En el estudio liderado por el CRG también han colaborado el Instituto de Bioingeniería de Cataluña (IBEC) y el Centro de Oftalmología Barraquer.
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