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Japón – 28/Dic/2021

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Investigadores de la Universidad japonesa de Yamagata anunciaron el pasado viernes que han descubierto que un fármaco en desarrollo para tratar el Alzhéimer también es efectivo en el potencial tratamiento de la esclerosis lateral amiotrófica (ELA).

Actualmente existen varios tratamientos que ralentizan el avance de la enfermedad, pero este medicamento en desarrollo sería el primero en trabajar directamente en la acumulación de proteína en el cerebro y la médula espinal, según aseguró el director del centro de investigación sobre ELA del Hospital Nacional de Yamagata, Takeo Kato.

El equipo de investigadores logró durante sus estudios frenar con éxito la acumulación de esta proteína en ratones con ELA al administrarles el fármaco experimental. Los experimentos se realizaron en ratones con ELA hereditaria, la menos común, por lo que ahora se procederá a estudiar la efectividad del medicamento en sujetos con ELA esporádica, la más frecuente.

Los investigadores esperan poder comenzar un estudio clínico con humanos en 2024, en el camino para encontrar un tratamiento contra esta grave enfermedad que afecta a 5 de cada 100.000 personas en todo el mundo, tiene una alta mortalidad y provoca parálisis muscular progresiva por la acumulación de proteínas en las neuronas.

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