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Japón – 10/Mar/2022
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Los investigadores de Tokyo Medical and Dental (TMDU) desarrollan tendones artificiales in vitro a partir de células madre humanas que pueden corregir lesiones tendinosas comunes, como la ruptura del tendón de Aquiles.
Los tendones son tejidos que conectan los músculos a los huesos y son importantes para el movimiento y la locomoción. Las lesiones de los tendones son bastante comunes, con millones de personas, principalmente atletas, afectadas en todo el mundo y, a menudo, pueden tardar muchos meses en recuperarse, lo que afecta significativamente la calidad de vida.
Además, si bien existen muchas opciones de tratamiento, ninguna de ellas es la cura perfecta y muchas provocan dolor, inmunogenicidad o fracaso del tratamiento a largo plazo. Por lo tanto, se necesita una nueva estrategia terapéutica para la reparación del tendón.
En un estudio publicado en Revista de ingeniería de tejidos En enero de 2022, investigadores de la Universidad Médica y Dental de Tokio (TMDU) indujeron con éxito células madre humanas para crear un tejido similar a un tendón artificial que imita las propiedades del tendón y ofrece una reconstrucción del tendón significativamente mejorada en un modelo de rotura de tendón de ratón.
Estas células madre que expresan Mohawk se colocaron luego en un sistema de cultivo 3D especializado que ejerce fuerza mecánica sobre las células a medida que crecen. Esto simula las condiciones para el desarrollo del tendón y mejora la alineación y organización de las células, lo que les permite crear tejido similar al tendón.
Estos resultados prometedores sugieren que una nueva estrategia médica para la reparación de tendones puede estar clínicamente disponible en el futuro.
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