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México- 18/Ago/2021
[/fusion_title][fusion_separator style_type=»default» hide_on_mobile=»small-visibility,medium-visibility,large-visibility» sticky_display=»normal,sticky» class=»» id=»» flex_grow=»0″ top_margin=»» bottom_margin=»50px» width=»» alignment=»center» border_size=»» sep_color=»» icon=»» icon_size=»» icon_color=»» icon_circle=»» icon_circle_color=»» /][fusion_text columns=»» column_min_width=»» column_spacing=»» rule_style=»default» rule_size=»» rule_color=»» content_alignment_medium=»» content_alignment_small=»» content_alignment=»» hide_on_mobile=»small-visibility,medium-visibility,large-visibility» sticky_display=»normal,sticky» class=»» id=»» margin_top=»» margin_right=»» margin_bottom=»» margin_left=»» font_size=»» fusion_font_family_text_font=»» fusion_font_variant_text_font=»» line_height=»» letter_spacing=»» text_color=»#000000″ animation_type=»» animation_direction=»left» animation_speed=»0.3″ animation_offset=»»]
Paola Castillo Juárez, científica del Instituto Politécnico Nacional (IPN), desarrolla un biofármaco a partir del diseño de cuatro péptidos (pequeños fragmentos de proteínas), los cuales una vez sintetizados probaron tener una eficacia por encima del 90% contra la replicación del COVID-19, que el día de ayer registró una cifra récord de contagios.
Es decir, esta investigación representa una alternativa viable para el tratamiento para el COVID-19; en breve se iniciarán los trámites de la patente.
De acuerdo con un comunicado del IPN, Castillo Juárez, de la Escuela Nacional de Ciencias Biológicas (ENCB), señaló que los componentes del fármaco se evalúan en el Instituto Nacional de Enfermedades Respiratorias (INER) directamente con el coronavirus aislado de pacientes. Además, dice que los resultados son alentadores.
En ese sentido, la experta detalló que el péptido dirigido a la proteína S del SARS-CoV-2 evita los cambios conformacionales que se necesitan para que el virus entre a las células, mientras que la molécula enfocada al receptor celular de la enzima convertidora de la angiotensina 2 (ACE2) bloquea la unión de la proteína viral con este receptor.
Finalmente Castillo Juárez precisó que en la siguiente etapa del proyecto, que esperan concluir al término de 2021, probarán los péptidos in vivo (modelo animal) y a principios de 2022 prevén comenzar la etapa clínica y solicitar el apoyo del INER para evaluarlo con pacientes de ese centro hospitalario.
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