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Internacional – 19/Nov/2021
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La farmacéutica AstraZeneca informó los resultados del anticuerpo monoclonal denominado AZD7442 para proteger por un año y reducir hasta en 83 por ciento el riesgo de complicación, hospitalización y mortalidad por SARSCoV-2 entre paciente crónicos con alguna inmunosupresión por VIH, afección renal y cardíaca, trasplantados, con cáncer.
Jesús Abraham Simón Campos, especialista en medicina interna, inmunología y reumatología, explicó que el fármaco, integrado con una combinación de dos anticuerpos monoclonales (tixagevimab y cilgavimab), es preventivo aunque también es efectivo como tratamiento entre los pacientes infectados que, por su condición clínica, perdieron la inmunidad protectora otorgada por la vacunación contra covid.
Detalló que un aspecto relevante de dicho anticuerpo monoclonal es que al aplicarse una sola dosis las personas quedarán protegidas por el lapso de un año contra el virus pandémico y todas sus variantes de preocupación, siendo Delta el linaje predominante en México y diversas partes del mundo.
AstraZeneca liberó hoy los resultados de dos estudios fase 3: el Provent, que involucró en el ensayo clínico (NCT04625725) a 5 mil 197 voluntarios sin vacunar y sin haber tenido contacto con el virus procedentes de 87 centros sanitarios de Estados Unidos, Reino Unido, España, Francia y Bélgica, y el Tackle (NCT04723394), con 910 participantes con infección confirmada por PCR, con riesgo de desarrollar un cuadro de covid-19 grave.
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